1: \(=5xy^2\cdot9y^2=45xy^4\)
2: \(=-8\cdot x^2yz\cdot x^3y^3=-8x^5y^4z\)
3: \(=4x^4y^2\cdot8x^3yz^3=32x^7y^3z^3\)
4: \(=4x^2y^6\cdot\left(-8\right)\cdot x^3y^3z^3=-32x^5y^9z^3\)
5: \(=-5xy^3z\cdot16x^4=-80x^5y^3z\)
6: \(=4x^4y^6\cdot\left(-2\right)xy=-8x^5y^7\)